Deer antler stem cells are a novel type of cells that sustain full regeneration of a mammalian organ-deer antler.

ABSTRACT: Deer antlers are extraordinary mammalian organs that can fully regenerate annually. Antler renewal is a stem cell-based epimorphic process and antler stem (AS) cells can initiate de novo generation of antlers in postnatal mammals. However, although being called stem cells, the AS cells have not been characterized at molecular level based on the stem cell criteria. Comprehensive characterization of the AS cells would undoubtedly help to decipher the mechanism underlying the full regeneration of deer antlers, the only case of stem cell-based epimorphic regeneration in mammals. In the present study, three types of AS cells (antlerogenic periosteal cells APCs, for initial pedicle and first antler formation; pedicle periosteal cells PPC, for annual antler regeneration; and reserve mesenchyme ce

SUBMITTER: Wang D 

PROVIDER: S-EPMC6549167 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature