Developing regulatory property of gelatin-tannic acid multilayer films for coating-based nitric oxide gas delivery system.

ABSTRACT: To utilize potentials of nitric oxide (NO) gas in anti-bacterial, anticancer, wound healing applications, numerous studies have been conducted to develop a NO delivery system in the past few decades. Even though a coating method and film types are essential to apply in biomedical device coating from previous NO delivery systems, release control from the coating system is still challenging. In this study, we introduced a multilayered polymeric coating system to overcome the uncontrollable NO release kinetics of film systems. We used biocompatible gelatin and tannic acid to construct a rough, porous structured film based on the layer-by-layer self-assembly method. The multilayered polymeric structure facilitated the controlled amount of NO release from (Gel/TA)_n film and showed bu

SUBMITTER: Park K 

PROVIDER: S-EPMC6549184 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature