Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients.

ABSTRACT:

Background

Infection is the second most common cause of mortality for patients with end-stage renal disease (ESRD), accompanying with immune dysfunction. Endothelin (EDN) is known to be related to inflammation; however, it is unknown whether genetic variants of the EDN gene family are associated with increased risk of hospitalized infection events.

Methods

Nineteen tagging single-nucleotide polymorphisms (tSNPs) of the EDN gene family were selected for genotyping a cohort of 190 ESRD patients. Patient demographics were recorded, the subtypes of infection events were identified, and association analysis between the EDN genetic variants and hospitalized infection events was performed.

Results

In this study, 106 patients were hospitalized for infection events. The leadin

SUBMITTER: Kao CC 

PROVIDER: S-EPMC6549338 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature