Similar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols.

ABSTRACT:

Background

Mouse models have been extremely valuable in identifying the fundamental mechanisms of airway inflammation that underlie human allergic asthma. Several models are commonly used, employing different methods and routes of sensitisation, and allergens of varying clinical relevance. Although all models elicit similar hallmarks of allergic airway inflammation, including airway eosinophilia, goblet cell hyperplasia and cellular infiltration in lung, it is not established whether they do so by involving the same mechanisms.

Results

We compared the impact of inactivation of various innate or adaptive immune genes, as well as sex, in different models of allergic airway inflammation in mice of C57BL/6 background. Chicken ovalbumin (OVA) and house dust mite (HDM) were used a

SUBMITTER: Hyde EJ 

PROVIDER: S-EPMC6549380 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature