African KhoeSan ancestry linked to high-risk prostate cancer.

ABSTRACT:

Backgrounds

Genetic diversity is greatest within Africa, in particular the KhoeSan click-speaking peoples of southern Africa. South African populations represent admixture fractions including differing degrees of African, African-KhoeSan and non-African genetic ancestries. Within the United States, African ancestry has been linked to prostate cancer presentation and mortality. Together with environmental contributions, genetics is a significant risk factor for high-risk prostate cancer, defined by a pathological Gleason score ≥ 8.

Methods

Using genotype array data merged with ancestry informative reference data, we investigate the contribution of African ancestral fractions to high-risk prostate cancer. Our study includes 152 South African men of African (Black) or African-a

SUBMITTER: Petersen DC 

PROVIDER: S-EPMC6549381 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature