Neurocognitive Pathways in Attention-Deficit/Hyperactivity Disorder and White Matter Microstructure.

ABSTRACT:

Background

This study sought to identify attention-deficit/hyperactivity disorder (ADHD) abnormalities in relationships between brain white matter structure and individual differences in several types of impulsive behavior.

Methods

Adolescents, n = 67 with ADHD combined subtype and n = 68 without ADHD, were given neuropsychological tests and underwent diffusion tensor imaging scans. Principal component analysis reduced test scores into factors representing different types of impulsive behavior. Tract-based spatial statistics quantified white matter integrity in relationship to components of impulsive behavior. ADHD versus non-ADHD differences in the strength and nature of linear relationships between regional white matter and three impulsivity components were examined using

SUBMITTER: Bessette KL 

PROVIDER: S-EPMC6549508 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature