Determinants of Macular Layers and Optic Disc Characteristics on SD-OCT: The Rhineland Study.

ABSTRACT:

Purpose

To investigate variation and determinants of macular layers, peripapillary retinal nerve fiber layer (pRNFL) and Bruch's membrane opening-minimum rim width (BMO-MRW) in the general population.

Methods

In 1306 participants, we performed spectral domain optical coherence tomography (SD-OCT) scans of the macula, pRNFL, and BMO-MRW, and assessed their determinants using multivariable regression. Intraindividual interocular differences were analyzed using Spearman's rank correlation analysis.

Results

Participant age ranged from 30 to 95 years (mean ± standard deviation, 56.1 ± 13.9) and 56% were women. Interocular correlation ranged from 0.63 to 0.93. Differences increased with age and were larger in persons with glaucoma or prior stroke. pRNFL and BMO-MRW decrease

SUBMITTER: Mauschitz MM 

PROVIDER: S-EPMC6549562 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature