Transient states of network connectivity are atypical in autism: A dynamic functional connectivity study.

ABSTRACT: There is ample evidence of atypical functional connectivity (FC) in autism spectrum disorders (ASDs). However, transient relationships between neural networks cannot be captured by conventional static FC analyses. Dynamic FC (dFC) approaches have been used to identify repeating, transient connectivity patterns ("states"), revealing spatiotemporal network properties not observable in static FC. Recent studies have found atypical dFC in ASDs, but questions remain about the nature of group differences in transient connectivity, and the degree to which states persist or change over time. This study aimed to: (a) describe and relate static and dynamic FC in typical development and ASDs, (b) describe group differences in transient states and compare them with static FC patterns, and (c) examine

SUBMITTER: Mash LE 

PROVIDER: S-EPMC6549695 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature