Anti-vascular endothelial growth factor treatment for retinal conditions: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To evaluate the comparative effectiveness and safety of intravitreal bevacizumab, ranibizumab and aflibercept for patients with choroidal neovascular age-related macular degeneration (cn-AMD), diabetic macular oedema (DMO), macular oedema due to retinal vein occlusion (RVO-MO) and myopic choroidal neovascularisation (m-CNV).

Design

Systematic review and random-effects meta-analysis.

Methods

Multiple databases were searched from inception to 17 August 2017. Eligible head-to-head randomised controlled trials (RCTs) comparing the (anti-VEGF) drugs in adult patients aged ≥18 years with the retinal conditions of interest. Two reviewers independently screened studies, extracted data and assessed risk of bias.

Results

19 RCTs involving 7459 patients with cn

SUBMITTER: Pham B 

PROVIDER: S-EPMC6549720 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature