Systematic review and meta-analysis of clinical significance of autoantibodies for idiopathic pulmonary fibrosis.

ABSTRACT:

Objective

To clarify clinical significance of the sole presence of autoantibodies for idiopathic pulmonary fibrosis (IPF) without any other symptoms or signs suggestive of autoimmune disease.

Design

Systematic review and meta-analysis DATA SOURCES: Medline, EMBASE, Science Citation Index Expanded and Google Scholar were searched from 1 January 2002 through 12 February 2019.

Eligibility criteria for selecting studies

Primary studies addressing all-cause mortality and the development of a defined autoimmune disease for IPF with autoantibodies were included for the review.

Data extraction and synthesis

Two reviewers extracted relevant data and assessed risk of bias independently. Meta-analysis was conducted using a random-effects model if three or more studies rep

SUBMITTER: Kamiya H 

PROVIDER: S-EPMC6550002 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature