Statuses of food-derived glutathione in intestine, blood, and liver of rat.

ABSTRACT: Oral administration of glutathione has been demonstrated to reduce exercise-induced fatigue and improve liver function, although glutathione can be synthesized in the liver. However, little is known about the underlying mechanism of this effect. To address this, the status of food-derived glutathione in the intestine, blood, and liver was examined. Glutathione-1-¹³C or N-acetyl-cysteine-1-¹³C (NAC) was orally administered to rats (50 mg/kg). Food-derived glutathione contents within tissues were estimated by subtracting endogenous glutathione-1-¹³C from the total glutathione-1-¹³C. Food-derived glutathione was present in rat intestines and livers (approximately 60 and 300 μmol/kg, respectively, 120 min after ingestion) in electrochemically

SUBMITTER: Yamada H 

PROVIDER: S-EPMC6550177 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature