Impact of predictive medicine on therapeutic decision making: a randomized controlled trial in congenital heart disease.

ABSTRACT: Computational modelling has made significant progress towards clinical application in recent years. In addition to providing detailed diagnostic data, these methods have the potential to simulate patient-specific interventions and to predict their outcome. Our objective was to evaluate to which extent patient-specific modelling influences treatment decisions in coarctation of the aorta (CoA), a common congenital heart disease. We selected three cases with CoA, two of which had borderline indications for intervention according to current clinical guidelines. The third case was not indicated for intervention according to guidelines. For each case, we generated two separate datasets. First dataset included conventional diagnostic parameters (echocardiography and magnetic resonance imaging). I

SUBMITTER: Naci H 

PROVIDER: S-EPMC6550204 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature