Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study.

ABSTRACT:

Background

Pancreatic tumor cells may avoid immune surveillance by releasing the transmembrane major histocompatibility complex class I chain-related A (MICA) protein in soluble form (s-MICA). We hypothesized that the presence of the A5.1 polymorphism in the MICA gene, which encodes a truncated MICA protein, is associated with higher s-MICA levels and increased pancreatic cancer risk.

Methods

MICA alleles and s-MICA levels were measured in 121 pancreatic cancer cases and 419 controls. General linear regression with a log transformation assessed geometric means of s-MICA levels across MICA alleles. Unconditional logistic regression was used to calculate the odds ratio (OR) and 95% confidence intervals (CI) for pancreatic cancer associated with MICA alleles.

Results

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SUBMITTER: Onyeaghala G 

PROVIDER: S-EPMC6550421 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature