Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine.

ABSTRACT:

Objective

To identify a plasma metabolomic biomarker signature for migraine.

Methods

Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a ¹H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test analysis was performed to identify sets of related metabolites associated with migraine. The Holm procedure was applied to control the family-wise error rate at 5% in single-metabolite and global test analy

SUBMITTER: Onderwater GLJ 

PROVIDER: S-EPMC6550500 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature