A prospective study of serum metabolites and risk of ischemic stroke.

ABSTRACT:

Objective

To identify promising blood-based biomarkers and novel etiologic pathways of disease risk, we applied an untargeted serum metabolomics profiling in a community-based prospective study of ischemic stroke (IS).

Methods

In 3,904 men and women from the Atherosclerosis Risk In Communities study, Cox proportional hazard models were used to estimate the association of incident IS with the standardized level of 245 fasting serum metabolites individually, adjusting for age, sex, race, field center, batch, diabetes, hypertension, current smoking status, body mass index, and estimated glomerular filtration rate. Validation of results was carried out in an independent sample of 114 IS cases and 112 healthy controls.

Results

Serum levels of 2 long-chain dicarboxylic acid

SUBMITTER: Sun D 

PROVIDER: S-EPMC6550501 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature