MON-092 Role of Genetic Variants of NNMT rs694539 and rs1941404, FTO rs1421085 and Irx3 rs3751723 Polymorphisms on Resting Energy Expenditure and BMI

ABSTRACT: Abstract In obesity the NNMTrs694539 polymorphism associates with cardiovascular damage and nonalcoholic steatohepatitis, and rs1941404 with hyperlipidemia.NNMT (Nicotidamide-N-methyltransferase) is a regulator of adiposity and energy expenditure correlating with BMIand energy metabolism. FTOrs1421085 polymorphism regulates food behavior, and IRX3rs3751723 is associated with obesity risk.Resting energy expenditure (REE) is an essential component of obesity. To evaluate the role of NNMTrs694539 and rs1941404,and FTOrs1421085 and IRX3rs3751723 polymorphisms on REEand BMI. We recruited 200 healthy subjects 30 to 50 years of age, 100 non-obese (BMI 18.5-29.5) and 100 obese (BMI ≥30 kg/m2). and REE evaluated by indirect calorimetry. A fasting blood sample was obtained for metabolites and DNA ex

SUBMITTER: Banales Luna M 

PROVIDER: S-EPMC6550987 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature