Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen.

ABSTRACT: T cell responses to symbionts in the intestine drive tolerance or inflammation depending on the genetic background of the host. These symbionts in the gut sense the available nutrients and adapt their metabolic programs to use these nutrients efficiently. Here, we ask whether diet can alter the expression of a bacterial antigen to modulate adaptive immune responses. We generated a CD4+ T cell hybridoma, BθOM, specific for Bacteroides thetaiotaomicron (B. theta). Adoptively transferred transgenic T cells expressing the BθOM TCR proliferated in the colon, colon-draining lymph node, and spleen in B. theta-colonized healthy mice and differentiated into regulatory T cells (Tregs) and effector T cells (Teffs). Depletion of B. theta-specific Tregs resulted in colitis, showing that a single protei

SUBMITTER: Wegorzewska MM 

PROVIDER: S-EPMC6550999 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature