Alterations in White Matter Microstructure and Connectivity in Young Adults with Alcohol Use Disorder.

ABSTRACT:

Background

Magnetic resonance imaging (MRI) studies have shown differences in volume and structure in the brains of individuals with alcohol use disorder (AUD). Most research has focused on neuropathological effects of alcohol that appear after years of chronic alcohol misuse. However, few studies have investigated white matter (WM) microstructure and diffusion MRI-based (DWI) connectivity during early stages of AUD. Therefore, the goal of this work was to investigate WM integrity and structural connectivity in emerging adulthood AUD subjects using both conventional DWI metrics and a novel connectomics approach.

Methods

Twenty-two AUD and 18 controls (CON) underwent anatomic and diffusion MRI. Outcome measures were scalar diffusion metrics and structural network connectomes.

SUBMITTER: Chumin EJ 

PROVIDER: S-EPMC6551253 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature