Genome-wide analyses of psychological resilience in U.S. Army soldiers.

ABSTRACT: Though a growing body of preclinical and translational research is illuminating a biological basis for resilience to stress, little is known about the genetic basis of psychological resilience in humans. We conducted genome-wide association studies (GWASs) of self-assessed (by questionnaire) and outcome-based (incident mental disorders from predeployment to postdeployment) resilience among European (EUR) ancestry soldiers in the Army study to assess risk and resilience in servicemembers. Self-assessed resilience (N = 11,492) was found to have significant common-variant heritability (h² = 0.162, se = 0.050, p = 5.37 × 10^-4 ), and to be significantly negatively genetically correlated with neuroticism (r_g  = -0.388, p = .0092). GWAS results from the EUR soldie

SUBMITTER: Stein MB 

PROVIDER: S-EPMC6551278 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature