Metabolomic assessment of exposure to near-highway ultrafine particles.

ABSTRACT: Exposure to traffic-related air pollutants has been associated with increased risk of adverse cardiopulmonary outcomes and mortality; however, the biochemical pathways linking exposure to disease are not known. To delineate biological response mechanisms associated with exposure to near-highway ultrafine particles (UFP), we used untargeted high-resolution metabolomics to profile plasma from 59 participants enrolled in the Community Assessment of Freeway Exposure and Health (CAFEH) study. Metabolic variations associated with UFP exposure were assessed using a cross-sectional study design based upon low (mean 16,000 particles/cm³) and high (mean 24,000 particles/cm³) annual average UFP exposures. In comparing quantified metabolites, we identified five metabolites that w

SUBMITTER: Walker DI 

PROVIDER: S-EPMC6551325 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature