Obesity and Weight Gain Since Early Adulthood Are Associated With a Lower Risk of Microscopic Colitis.

ABSTRACT:

Background & aims

Obesity promotes intestinal inflammation and might contribute to the pathogenesis of inflammatory bowel disease. We examined the association between obesity and risk of microscopic colitis in a prospective cohort study.

Methods

We collected data from 192,101 women enrolled in the Nurses' Health Study (NHS) (from 1986 through 2014) or the NHSII (from 1991 through 2015). Anthropomorphic and lifestyle information were self-reported biennially. Obesity was defined using body mass index (BMI). Microscopic colitis was confirmed by review of medical records. We used Cox proportional hazard models to estimate adjusted hazard ratios (aHRs) and 95% CIs.

Results

Among the participants in the NHS and NHSII, we confirmed 244 cases of microscopic colitis during 4,

SUBMITTER: Liu PH 

PROVIDER: S-EPMC6551326 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature