Solving for X: Evidence for sex-specific autism biomarkers across multiple transcriptomic studies.

ABSTRACT: Autism spectrum disorder (ASD) is a markedly heterogeneous condition with a varied phenotypic presentation. Its high concordance among siblings, as well as its clear association with specific genetic disorders, both point to a strong genetic etiology. However, the molecular basis of ASD is still poorly understood, although recent studies point to the existence of sex-specific ASD pathophysiologies and biomarkers. Despite this, little is known about how exactly sex influences the gene expression signatures of ASD probands. In an effort to identify sex-dependent biomarkers and characterize their function, we present an analysis of a single paired-end postmortem brain RNA-Seq data set and a meta-analysis of six blood-based microarray data sets. Here, we identify several genes with sex-depende

SUBMITTER: Lee SC 

PROVIDER: S-EPMC6551334 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature