Dissecting the Heterogeneous Cortical Anatomy of Autism Spectrum Disorder Using Normative Models.

ABSTRACT:

Background

The neuroanatomical basis of autism spectrum disorder (ASD) has remained elusive, mostly owing to high biological and clinical heterogeneity among diagnosed individuals. Despite considerable effort toward understanding ASD using neuroimaging biomarkers, heterogeneity remains a barrier, partly because studies mostly employ case-control approaches, which assume that the clinical group is homogeneous.

Methods

Here, we used an innovative normative modeling approach to parse biological heterogeneity in ASD. We aimed to dissect the neuroanatomy of ASD by mapping the deviations from a typical pattern of neuroanatomical development at the level of the individual and to show the necessity to look beyond the case-control paradigm to understand the neurobiology of ASD. We fi

SUBMITTER: Zabihi M 

PROVIDER: S-EPMC6551348 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature