Enhancement of rotator cuff tendon-bone healing using bone marrow-stimulating technique along with hyaluronic acid.

ABSTRACT:

Objective

The purpose of this study was to investigate the effect of hyaluronic acid (HA) in the tendon-bone healing process after rotator cuff repair in a rabbit model.

Methods

In vitro, rat bone marrow stromal cells (rBMSCs) were cultured in media for cartilage-related and inflammation-related gene expression levels examination at 1.0 mg/mL of HA. In vivo, 48 New Zealand white rabbits underwent rotator cuff repair surgery, and they were randomly divided into three groups: (1) control group (n = 16), (2) microfracture (MF) group accepting MF treatment (n = 16) and (3) MF/HA group accepting MF with HA treatment (n = 16). Four rabbits from each group were sacrificed at 6 and 12 weeks postoperatively for histological evaluation and biomechanical testing.

Results

In vitr

SUBMITTER: Li H 

PROVIDER: S-EPMC6551361 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature