Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis.

ABSTRACT:

Objective

Scoliosis is a common disease characterized by spinal curvature with variable severities. There is no generally accepted theory about the physical origin of the spinal deformation of scoliosis. The aim of this study was to explore a new hypothesis suggesting that the curvatures in scoliosis may be associated with the imbalance growth between thoracic vertebral column and sternum.

Methods

We undertook a comparative computed tomography (CT) based morphology study of thoracic vertebrae and sternum of patients with adolescent idiopathic scoliosis (AIS) and age-gender matched normal subjects. We further measured the ratios between the lengths of the sternum and thoracic vertebra of mice with deficiency of fibroblast growth factor receptor 3 (FGFR3), which exhibit scolio

SUBMITTER: Chen B 

PROVIDER: S-EPMC6551366 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature