Neuronal autoantibodies associated with cognitive impairment in melanoma patients.

ABSTRACT:

Background

Cancer-related cognitive impairment is an important complication in cancer patients, yet the underlying mechanisms remain unknown. Over the last decade, the field of paraneoplastic neurological syndromes has been dramatically changed by the discovery of new neuronal autoantibodies, some of them associated with cognitive impairment. We aimed to assess the prevalence of neuronal autoantibodies in melanoma patients and their association with neurological and cognitive dysfunction.

Patients and methods

A total of 157 consecutive melanoma patients with a median age of 63 years were recruited at the Department of Dermatology, Charité-Universitätsmedizin Berlin and tested for neuronal autoantibodies. A comprehensive neuropsychological assessment was carried out in a sele

SUBMITTER: Bartels F 

PROVIDER: S-EPMC6551450 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature