Application of Group I Metal Adduction to the Separation of Steroids by Traveling Wave Ion Mobility Spectrometry.

ABSTRACT: Steroids represent an interesting class of small biomolecules due to their use as biomarkers and their status as scheduled drugs. Although the analysis of steroids is complicated by the potential for many isomers, ion mobility spectrometry (IMS) has previously shown promise for the rapid separation of steroid isomers. This work is aimed at the further development of IMS separation for the analysis of steroids. Here, traveling wave ion mobility spectrometry (TWIMS) was applied to the study of group I metal adducted steroids and their corresponding multimers for five sets of isomers. Each set of isomers had a minimum of one dimeric metal ion adduct that exhibited a resolution greater than one (i.e., approaching baseline resolution). Additionally, ion-neutral collision cross sections (CCSs) w

SUBMITTER: Rister AL 

PROVIDER: S-EPMC6551524 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature