Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD.

ABSTRACT:

Introduction

Diagnosis of superimposed preeclampsia in women with chronic kidney disease (CKD) is complicated by the presence of hypertension and proteinuria due to renal disease. The aims of this study were to determine mechanistic links between superimposed preeclampsia and renin-angiotensin system activation, endothelial pathology, complement dysfunction, and tubular injury, and to explore the role of diagnostic indicators of superimposed preeclampsia.

Methods

Plasma and urinary biomarkers derived from the renin-angiotensin system (active renin, angiotensinogen), endothelial glycocalyx (hyaluronan, intercellular adhesion molecule, vascular cell adhesion molecule [VCAM], P-selectin, E-selectin), complement activation (C3a, C5a, complement factor H, C5b-9), and tubular inju

SUBMITTER: Wiles K 

PROVIDER: S-EPMC6551530 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature