Utilization of selenocysteine in early-branching fungal phyla.

ABSTRACT: Selenoproteins are a diverse group of proteins containing selenocysteine (Sec)-the twenty-first amino acid-incorporated during translation via a unique recoding mechanism^1,2. Selenoproteins fulfil essential roles in many organisms¹, yet are not ubiquitous across the tree of life^3-7. In particular, fungi were deemed devoid of selenoproteins^4,5,8. However, we show here that Sec is utilized by nine species belonging to diverse early-branching fungal phyla, as evidenced by the genomic presence of both Sec machinery and selenoproteins. Most fungal selenoproteins lack consensus Sec recoding signals (SECIS elements⁹) but exhibit other RNA structures, suggesting altered mechanisms of Sec insertion in fungi. Phylogenetic analyses support a scen

SUBMITTER: Mariotti M 

PROVIDER: S-EPMC6551623 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature