The long non-coding RNA H19 suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma.

ABSTRACT: The long non-coding RNA (lncRNA) H19 represents a maternally expressed and epigenetically regulated imprinted gene product and is discussed to have either tumor-promoting or tumor-suppressive actions. Recently, H19 was shown to be regulated under inflammatory conditions. Therefore, aim of this study was to determine the function of H19 in hepatocellular carcinoma (HCC), an inflammation-associated type of tumor. In four different human HCC patient cohorts H19 was distinctly downregulated in tumor tissue compared to normal or non-tumorous adjacent tissue. We therefore determined the action of H19 in three different human hepatoma cell lines (HepG2, Plc/Prf5, and Huh7). Clonogenicity and proliferation assays showed that H19 overexpression could suppre

SUBMITTER: Schultheiss CS 

PROVIDER: S-EPMC6551655 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature