Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma.

ABSTRACT: Glioblastoma, also known as glioblastoma multi-forme, is the most common and deadliest form of high-grade malignant brain tumors with limited available treatments. Within the glioblastoma tumor microenvironment (TME), tumor cells, stromal cells, and infiltrating immune cells continuously interact and exchange signals through various secreted factors including cytokines, chemokines, growth factors, and metabolites. Simultaneously, they dynamically reprogram their metabolism according to environmental energy demands such as hypoxia and neo-vascularization. Such metabolic re-programming can determine fates and functions of tumor cells as well as immune cells. Ultimately, glioma cells in the TME transform immune cells to suppress anti-tumor immune cells such as T, natural killer (NK) cells, an

SUBMITTER: Won WJ 

PROVIDER: S-EPMC6551710 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature