Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes.

ABSTRACT:

Background

Evidence of a protective role of autophagy in kidney diseases has sparked interest in autophagy as a potential therapeutic strategy. However, understanding how the autophagic process is altered in each disorder is critically important in working toward therapeutic applications.

Methods

Using cultured kidney proximal tubule epithelial cells (PTECs) and diabetic mouse models, we investigated how autophagic activity differs in type 1 versus type 2 diabetic nephropathy. We explored nutrient signals regulating starvation-induced autophagy in PTECs and used autophagy-monitoring mice and PTEC-specific autophagy-deficient knockout mice to examine differences in autophagy status and autophagy's role in PTECs in streptozotocin (STZ)-treated type 1 and db/db ty

SUBMITTER: Sakai S 

PROVIDER: S-EPMC6551771 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature