Changes in Albuminuria But Not GFR are Associated with Early Changes in Kidney Structure in Type 2 Diabetes.

ABSTRACT:

Background

In type 1 diabetes, changes in the GFR and urine albumin-to-creatinine ratio (ACR) are related to changes in kidney structure that reflect disease progression. However, such changes have not been studied in type 2 diabetes.

Methods

Participants were American Indians with type 2 diabetes enrolled in a clinical trial of losartan versus placebo. We followed a subset who underwent kidney biopsy at the end of the 6-year trial, with annual measurements of GFR (by urinary clearance of iothalamate) and ACR. Participants had a second kidney biopsy after a mean follow-up of 9.3 years. We used quantitative morphometric analyses to evaluate both biopsy specimens.

Results

Baseline measures for 48 participants (12 men and 36 women, mean age 45.6 years) who completed the

SUBMITTER: Looker HC 

PROVIDER: S-EPMC6551789 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature