SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms

ABSTRACT: Abstract The study aimed to determine the influence of DBP gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation. Out of 234 participants (126 females and 108 males), 146 had vitamin D deficiency (25(OH)D <50nmol/l) and were given 2000IU daily dose of vitamin D for 12 months. Two common single nucleotide polymorphisms (SNPs), (rs4588 and rs7041) of the DBP gene were assessed. Post supplementation median 25(OH)D was significantly higher [61.2 (46.3-76.8) and 66.6 (53.2-83.7)] in participants with CC genotype of rs4588 and GG genotype of rs7041 than other genotypes (p<0.001). Participants with T allele are 2.9 (1.9-4.5) times more likely to be a non-responder (unable to achieve serum 25(OH)D post-supplementation) than those with G allele (p<0.001). Participan

SUBMITTER: Al-Daghri N 

PROVIDER: S-EPMC6552145 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature