Development of ⁶⁸Ga-labelled ultrasound microbubbles for whole-body PET imaging.

ABSTRACT: Microbubble (MB) contrast agents have revolutionalised the way ultrasound (US) imaging can be used clinically and pre-clinically. Contrast-enhanced US offers improvements in soft-tissue contrast, as well as the ability to visualise disease processes at the molecular level. However, its inability to provide in vivo whole-body imaging can hamper the development of new MB formulations. Herein, we describe a fast and efficient method for achieving ⁶⁸Ga-labelling of MBs after a direct comparison of two different strategies. The optimised approach produces ⁶⁸Ga-labelled MBs in good yields through the bioorthogonal inverse-electron-demand Diel-Alder reaction between a trans-cyclooctene-modified phospholipid and a new tetrazine-bearing HBED-CC chelator. The abil

SUBMITTER: Hernandez-Gil J 

PROVIDER: S-EPMC6552490 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature