Critical transitions in malaria transmission models are consistently generated by superinfection.

ABSTRACT: The history of modelling vector-borne infections essentially begins with the papers by Ross on malaria. His models assume that the dynamics of malaria can most simply be characterized by two equations that describe the prevalence of malaria in the human and mosquito hosts. This structure has formed the central core of models for malaria and most other vector-borne diseases for the past century, with additions acknowledging important aetiological details. We partially add to this tradition by describing a malaria model that provides for vital dynamics in the vector and the possibility of super-infection in the human host: reinfection of asymptomatic hosts before they have cleared a prior infection. These key features of malaria aetiology create the potential for break points in the prevalen

SUBMITTER: Alonso D 

PROVIDER: S-EPMC6553601 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature