Characterizing herpes simplex virus type 1 and type 2 seroprevalence declines and epidemiological association in the United States.

ABSTRACT:

Objective

Assessing the epidemiological association between herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections in the United States, and characterizing the trends in the standardized HSV-1 and HSV-2 antibody prevalences (seroprevalences), 1999-2016.

Methods

Source of data was the cross-sectional and nationally-representative biennial surveys of the National Health and Nutrition Examination Survey (NHANES). All nine NHANES rounds for 1999-2016 were included in analysis. Datasets of these rounds were combined and analyzed accounting for survey design and applying weighting procedures. Logistic regressions were used to identify associations with seropositivity. Sensitivity analyses were conducted.

Results

Odds of HSV-1 infection declined by 2.84% (95% CI:

SUBMITTER: Chemaitelly H 

PROVIDER: S-EPMC6553692 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature