Predictors of early mortality and effectiveness of antiretroviral therapy in TB-HIV patients from Brazil.

ABSTRACT:

Background

The implementation of antiretroviral (ARV) therapy caused a significant decrease in HIV-associated mortality worldwide. Nevertheless, mortality is still high among people living with HIV/AIDS and tuberculosis (TB). ARV-naïve HIV patients coinfected with tuberculosis (TB) have more options to treat both diseases concomitantly. Nevertheless, some TB-HIV patients undertaking ARVs (ARV-experienced) are already failing the first line efavirenz-based regimen and seem to display different response to second line ARV therapy and exhibit other predictors of mortality.

Methods

We performed a retrospective cohort study including 273 patients diagnosed with TB-HIV and treated at a referral center in Rio de Janeiro, Brazil, between 2008 and 2016. Multivariate analysis and Cox

SUBMITTER: Demitto FO 

PROVIDER: S-EPMC6553696 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature