Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system.

ABSTRACT:

Objective

To describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated anomalies.

Methods

Data were abstracted from the Chinese Birth Defects Monitoring Network for the period 2007-2014. Birth prevalence of HPE were assessed by birth year, fetal/infant sex, maternal age, and maternal residential area. Poisson regressions were used to calculate the crude and adjusted prevalence ratios (PR) and their 95% confidence intervals, and linear chi-square test was used to explore time trend for the prevalence of HPE.

Results

A total of 1222 HPE cases were identified in 13,284,142 births, yielding an overall prevalence of 0.92 per 10,000 births. The annual prevalence of HPE presented an upward trend (P<0.001), from 0.54 per

SUBMITTER: Yi L 

PROVIDER: S-EPMC6553724 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature