Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets.

ABSTRACT: Regulatory T cells (Tregs) are required for the maintenance of immune tolerance and adoptive Treg infusion therapy has become a promising approach to suppress immune responses in diseases such as autoimmunity and transplant rejection. However, one critical challenge of Treg therapy is the requirement of in vitro expansion of functionally stable Tregs while preventing either the contamination of T effector and/or emergence of unstable pathogenic Tregs. Recent studies showing distinct metabolic requirements of T effectors and Tregs suggest that manipulation of cell metabolism may be an attractive strategy to achieve this goal. Here we show that human thymically derived Tregs (tTregs) and in vitro induced Tregs (iTregs) from naive T cells engage glycolysis equivalently upon activation. Howeve

SUBMITTER: Tanimine N 

PROVIDER: S-EPMC6553739 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature