Candida albicans white and opaque cells exhibit distinct spectra of organ colonization in mouse models of infection.

ABSTRACT: Candida albicans, a species of fungi, can thrive in diverse niches of its mammalian hosts; it is a normal resident of the GI tract and mucosal surfaces but it can also enter the bloodstream and colonize internal organs causing serious disease. The ability of C. albicans to thrive in these different host environments has been attributed, at least in part, to its ability to assume different morphological forms. In this work, we examine one such morphological change known as white-opaque switching. White cells are the default state of C. albicans, and most animal studies have been carried out exclusively with white cells. Here, we compared the proliferation of white and opaque cells in two murine models of infection and also monitored, using specially constructed strains, switching between th

SUBMITTER: Takagi J 

PROVIDER: S-EPMC6553767 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature