Isocaloric Fructose Restriction Reduces Serum d-Lactate Concentration in Children With Obesity and Metabolic Syndrome.

ABSTRACT:

Objective

To investigate the link between dietary sugar consumption and two separate pathogenetic mechanisms associated with metabolic syndrome: de novo lipogenesis (DNL) and nonenzymatic glycation.

Design and participants

We assessed changes in serum d-lactate (the detoxification end-product of methylglyoxal) concentration in response to 9 days of isocaloric fructose restriction in 20 children with obesity and metabolic syndrome, and examined correlations with changes in DNL, liver fat, insulin sensitivity, and other metrics of hepatic metabolism.

Interventions

Nine days of dietary sugar restriction, with substitution of equal amounts of refined starch.

Main outcome measures

On days 0 and 10, children had laboratory evaluation of d-lactate levels and other ana

SUBMITTER: Erkin-Cakmak A 

PROVIDER: S-EPMC6553815 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature