Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group.

ABSTRACT:

Purpose

To investigate relapse detection methods among children and adolescents with nongerminomatous malignant germ cell tumors (MGCTs) and to determine whether tumor markers alone might be sufficient for surveillance.

Methods

We retrospectively reviewed all patients enrolled in a phase III, single-arm trial for low-risk and intermediate-risk MGCTs. The method used to detect relapse was assessed based on case report forms, tumor markers, imaging, and pathology reports. Relapses were classified into one of two categories on the basis of whether they were (1) detectable by tumor marker elevation or (2) not detectable by tumor markers.

Results

A total of 302 patients were enrolled, and 284 patients had complete data for review. Seven patients had normal tumor markers at

SUBMITTER: Fonseca A 

PROVIDER: S-EPMC6553816 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature