Quantification of abnormal QRS peaks predicts response to cardiac resynchronization therapy and tracks structural remodeling.

ABSTRACT:

Background

Although QRS duration (QRSd) is an important determinant of cardiac resynchronization therapy (CRT) response, non-responder rates remain high. QRS fragmentation can also reflect electrical dyssynchrony. We hypothesized that quantification of abnormal QRS peaks (QRSp) would predict CRT response.

Methods

Forty-seven CRT patients (left ventricular ejection fraction = 23±7%) were prospectively studied. Digital 12-lead ECGs were recorded during native rhythm at baseline and 6 months post-CRT. For each precordial lead, QRSp was defined as the total number of peaks detected on the unfiltered QRS minus those detected on a smoothed moving average template QRS. CRT response was defined as >5% increase in left ventricular ejection fraction post-CRT.

Results

Sixty-perc

SUBMITTER: Suszko AM 

PROVIDER: S-EPMC6553860 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature