Comprehensive Analysis of Individual Variation in the Urinary Proteome Revealed Significant Gender Differences.

ABSTRACT: Disease biomarkers are the measurable changes associated with a pathophysiological process. Without homeostatic control, urine accumulates systematic changes in the body. Thus, urine is an attractive biological material for the discovery of disease biomarkers. One of the major bottlenecks in urinary biomarker discovery is that the concentration and composition of urinary proteins are influenced by many physiological factors. To elucidate the individual variation and related factors influencing the urinary proteome, we comprehensively analyzed the urine samples from healthy adult donors (aged 20-69 years). Co-expression network analysis revealed protein clusters representing the metabolic status, gender-related differences and age-related differences in urinary proteins. In particular, we d

SUBMITTER: Shao C 

PROVIDER: S-EPMC6553935 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature