Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts.

ABSTRACT:

Objective

To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.

Design

Individual participant data meta-analysis of 39 cohorts.

Setting

Europe, North America, and Oceania.

Population

265 270 births.

Methods

Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.

Main outcome measures

Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.

Results

Higher maternal pre-pregnancy BMI and gestational weight gain were, across their

SUBMITTER: Santos S 

PROVIDER: S-EPMC6554069 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature