Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota.

ABSTRACT:

Study question

Does altering gut microbiota with antibiotic treatment have any impact on endometriosis progression?

Summary answer

Antibiotic therapy reduces endometriosis progression in mice, possibly by reducing specific gut bacteria.

What is known already

Endometriosis, a chronic condition causing abdominal pain and infertility, afflicts up to 10% of women between the ages of 25 and 40, ~5 million women in the USA. Current treatment strategies, including hormone therapy and surgery, have significant side effects and do not prevent recurrences. We have little understanding of why some women develop endometriosis and others do not.

Study design, size, duration

Mice were treated with broad-spectrum antibiotics or metronidazole, subjected to surgically-induced e

SUBMITTER: Chadchan SB 

PROVIDER: S-EPMC6554192 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature