Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4⁺ T Cells in the Regulation of T Cell Differentiation.

ABSTRACT: It is now apparent that immune cells express a functional cholinergic system and that α7 nicotinic acetylcholine receptors (α7 nAChRs) are involved in regulating T cell differentiation and the synthesis of antigen-specific antibodies and proinflammatory cytokines. Here, we investigated the specific function α7 nAChRs on T cells and antigen presenting cells (APCs) by testing the effect of GTS-21, a selective α7 nAChR agonist, on differentiation of CD4⁺ T cells from ovalbumin (OVA)-specific TCR transgenic DO11.10 mice activated with OVA or OVA peptide_323-339 (OVAp). GTS-21 suppressed OVA-induced antigen processing-dependent development of CD4⁺ regulatory T cells (Tregs) and effector T cells (Th1, Th2, and Th17). By contrast, GTS-21 up-regulated OVAp-induced a

SUBMITTER: Mashimo M 

PROVIDER: S-EPMC6554293 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature