Comparative genomics provides new insights into the remarkable adaptations of the African wild dog (Lycaon pictus).

ABSTRACT: Within the Canidae, the African wild dog (Lycaon pictus) is the most specialized with regards to cursorial adaptations (specialized for running), having only four digits on their forefeet. In addition, this species is one of the few canids considered to be an obligate meat-eater, possessing a robust dentition for taking down large prey, and displays one of the most variable coat colorations amongst mammals. Here, we used comparative genomic analysis to investigate the evolutionary history and genetic basis for adaptations associated with cursoriality, hypercanivory, and coat color variation in African wild dogs. Genome-wide scans revealed unique amino acid deletions that suggest a mode of evolutionary digit loss through expanded apoptosis in the developing first digit. African wild dog-spe

SUBMITTER: Chavez DE 

PROVIDER: S-EPMC6554312 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature