Behavioral and Cognitive Improvement Induced by Novel Imidazoline I₂ Receptor Ligands in Female SAMP8 Mice.

ABSTRACT: As populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer's disease have become more common. I₂-Imidazoline receptors (I₂-IR) are widely distributed in the central nervous system, and dysregulation of I₂-IR in patients with neurodegenerative diseases has been reported, suggesting their implication in cognitive impairment. This evidence indicates that high-affinity selective I₂-IR ligands potentially contribute to the delay of neurodegeneration. In vivo studies in the female senescence accelerated mouse-prone 8 mice have shown that treatment with I₂-IR ligands, MCR5 and MCR9, produce beneficial effects in behavior and cognition. Changes in molecular pathways implicated in oxidative stress,

SUBMITTER: Grinan-Ferre C 

PROVIDER: S-EPMC6554384 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature